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While it is not currently licensed to treat dementia, research is rapidly evolving, and new insights are challenging the boundaries of how we view this medicationand the very nature of cognitive decline

doi: 10.1083/jcb.133.5.1007 146 NeumeisterENZhuYRichardSTerhorstCChanACShawAS

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They're not allowed to call themselves safe and effective because the FDA hasnt done their typical approval process, but that does not inherently mean that they're unsafe. There are some risks to know about, however

In the early stages of myocardial infarction, the Nrf2/Hmox1 pathway leads to iron overload and ferroptosis [168]