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Brain 140(7):18591871 Hoffmann J, Charles A (2018) Glutamate and its receptors as therapeutic targets for migraine
The most consistent results so far are grey matter alterations in the basal ganglia, areas of the limbic system such as the anterior cingulate cortex, hippocampus, insula, etc., and prefrontal areas like the orbitofrontal cortex, sometimes even more pronounced in association with self-reported fatigue or neurocognitive impairment [12, 35, 49]
Promethazine and chlorpromazine administration caused major changes in the treatment of allergy and psychiatric disorders, respectively
But what happens when levels of this mighty molecule become too low
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Infection and inflammation can be caused by bacterial exposure to lipopolysaccharides (LPS), which induce a cascade of responses from inflammation that results in fertility in males [5, 7]
