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A SURMOUNT-1 post-hoc analysis of 2,542 women, published in Obesity in 2025, found perimenopausal women on tirzepatide lost 23% of body weight against 3% on placebo, almost identical to the premenopausal result

15, the lower the purity of the intermediate, the more impurities are introduced into the intermediate or product, and particularly, the raw material Arg34GLP-1 (9-37) and the double-modified impurity which are difficult to remove are more easily obtained