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It has been proposed that GIP regulates inflammation and leukocyte adhesion through endothelin 1 while promoting vasodilation via nitric oxide secretion [109]
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MQC, which comprises four core modules (redox regulation, mitochondrial dynamics, autophagy, and biogenesis), is presumably a potential molecular hub that contributes to the maintenance of the hypometabolic phenotype and functional homeostasis of chondrocytes (33)
Citation: Minakova E, Lang J, Medel-Matus J-S, Gould GG, Reynolds A, Shin D, et al
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PMID 29477222
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