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[68] Evidence from microelectrode recordings from the brains of animals shows that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra are strongly activated by a wide variety of rewarding events

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No Human Adverse-Event Programme Without a controlled clinical development programme, the frequency and severity of possible adverse reactions cannot be estimated reliably

The appearance of mild-yellowish, mosaic symptoms was associated with a dramatic, 20-fold induction of defense-related genes like PR-1, chitinase and GST (Niehl et al., 2006)

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