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Importantly, these approaches reflect a paradigm shift from symptomatic treatment toward disease-modifying strategies that specifically address peripheral immune abnormalities contributing to central neurodegeneration

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NAC (N-acetylcysteine) as precursor: Rather than supplementing glutathione directly, NAC provides the rate-limiting amino acid (cysteine) for endogenous glutathione synthesis

The Advanced Lung Cancer Immuno-chemotherapy Study Group]