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If travelling to countries with extreme temperatures, consult your pharmacist about specialised cooling solutions

Depression There is emerging evidence that GLP-1 agonists may be directly beneficial in the treatment of depression, probably due to the interactions between the gut and the brain

Firstly, hydration is key

Abbreviations HGF: hepatocyte growth factor ICIs: immune checkpoint inhibitors TME: tumor microenvironment EMT: epithelial-mesenchymal transition HNSCC: head and neck squamous cell carcinoma RTKs: receptor tyrosine kinases METex14: MET exon 14 skipping mutations NSCLC: non-small cell lung cancer CAFs: cancer-associated fibroblasts TAMs: tumor-associated macrophages MDSCs: myeloid-derived suppressor cells NK: natural killer DCs: dendritic cells ECM: extracellular matrix Chi3L1: chitinase-3-like-1 Treg: T regulatory CRC: colorectal cancer GC: gastric cancer IL-6R: interleukin-6 receptor MMPs: matrix metalloproteinases HIF1: hypoxia-inducible factor 1 IFN-: interferon-gamma HCC: hepatocellular carcinoma CTLs: cytotoxic T lymphocytes MSCs: Mesenchymal stromal cells CTLA-4: cytotoxic T-lymphocyte-associated protein 4 APCs: antigen-presenting cells ORR: objective response rate PFS: progression-free survival OS: overall survival GSK3: glycogen synthase kinase 3 References Knowles LM, Stabile LP, Egloff AM, Rothstein ME, Thomas SM, Gubish CT, Lerner EC, Seethala RR, Suzuki S, Quesnelle KM, et al

Nicotinamide (Vitamin B3) This is also known as Niacinamide and is required by the liver's phase one detoxification system

It works by transporting fatty acids into the mitochondria, where they are burned for fuel