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It is when we see moderate to high numbers of these oxidant changes in RBCs (very large or multiple Heinz bodies in cats, eccentrocytes with Heinz bodies in a dog, eccentrocytes or Heinz bodies in a horse) that we attribute an anemia to oxidative injury

Erythrocytes affect hemostasis and thrombosis by altering blood viscosity, blood flow dynamics, secreting RBC-derived microvesicles, interactions with platelets or endothelial cells, fibrinogen-induced RBC aggregation, activation of blood coagulation factors, direct modulation of thrombin and fibrin formation, or formation of polyhedral-like erythrocytes in thrombi [47,48,49]

6 AssuncaoM.AndradeJ

This dual role, stimulating both synthesis and controlled degradation, is characteristic of wound healing rather than simple collagen accumulation

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