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Tirzepatide activates both GIP and GLP-1 pathways, while semaglutide is a GLP-1 receptor agonist
Here is a framework based on the clinical evidence
Shen J, Yu X, Zhuang Y, Kong Y, Zhao J, Yao Z
Patients should contact their GP or prescribing clinician if they experience any of the following: Severe or worsening fatigue that significantly impairs daily activities, work performance, or quality of life should be assessed
Pompili M, Venturini P, Palermo M, Stefani H, Seretti ME, Lamis DA, et al
Laufer, P
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