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32 Contrary to early skin model studies, Hernandez et al 32 found only low or inconsistent levels of ROS and AGEs in systemic models, suggesting that DNA damage is not primarily ROS-mediated and instead may occur through mechanisms such as glycation or crosslinking of DNA repair proteins

A helpful framework comes from insulin titration

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Low-Fat Diet for Arteries A long-term study in people with coronary heart disease compared the effects of a Mediterranean diet rich in olive oil with a low-fat diet

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Stewart CA, Reid IC