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preclinical safety evaluation found no genotoxicity, mutagenicity, or organ toxicity at tested doses

Some patients find that IV hydration therapy helps manage the dehydration and fatigue that can accompany the early adjustment period, particularly if nausea makes oral hydration challenging

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Greco, Esmeralda Capristo, Giuseppe Benedetti, Annalisa Giancaterini, Andrea De Gaetano, and Giovanni Gasbarrini (1999)

Within a year, participants regained about two-thirds of the weight they had lost, and said goodbye to some of the improvements in blood pressure, blood sugar and cholesterol they had achieved, according to the landmark STEP 1 extension trial

10.1111/j.1471-4159.2011.07478.x 326 LazarA