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Both responses are real, and neither is unusual

Storage and handling requirements vary by compound class, format, and batch

If an opened vial or reconstituted peptide freezes, the risk of damage to the peptides structure (denaturation) is very high, and wed recommend discarding it

A 2015 rabbit osteoarthritis model found that intra-articular injection of AOD-9604, particularly combined with hyaluronic acid, improved cartilage integrity and reduced joint degradation