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We werent sure that we would see an effect as quickly as we did, so I think it makes sense that the effect we did see was relatively modest. The protective benefits with GLP-1 receptor agonists appeared strongest against colon cancer (HR = 0.84
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The global methylation status showed significantly increased 5-mC levels in GCLC knockdown cells (Fig
30,31 On one hand, neuro-signals mediated by GLP-1 activation regulate food intake by controlling appetite and satiety and modulate endocrine organs like the pancreas, thus affecting overall metabolism
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