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Its defining structural feature is the gamma-glutamyl linkage: the glutamate residue is joined through its side-chain carboxyl rather than the usual alpha-peptide bond, which makes the molecule resistant to most intracellular peptidases and means it is cleaved almost exclusively by gamma-glutamyl transpeptidase at the outer cell surface (Zhang, Forman and Choi, Methods in Enzymology, 2005)
Rather than mimicking GHRH, it activates the second growth hormone release pathway
This reduced form of the coenzyme is then a substrate for any of the reductases in the cell that need to transfer hydrogen atoms to their substrates
The topical can be sprayed on any part of the body, making it an effortless addition to a daily wellness regimen
That does not mean one is universally better
found that creams containing GHK-Cu significantly improved skin firmness, density, laxity, and wrinkle reduction around the eyes and face
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