Alcohol consumption: Regular or heavy drinking depletes glutathione and increases oxidative stress, counteracting supplementation benefits
89 Under nutrient-replete conditions, these events occur in a heterogeneous manner and correlate closely with the emergence of necrotic-like vs apoptotic-like phenotypes, suggesting that lysosomal destabilization acts as a tipping point for synchronized death execution
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Examining contributions of ARG1-instigated arginine catabolism therein, we next generated Arg1 fl/fl Cx3cr1 -Cre animals by crossing Arg1 fl/fl mice with animals constitutively expressing Cre recombinase under the control of the Cx3cr1 promoter, generating BMDMs from both genotypes
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