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Higher concentrations (10mg/mL or greater) reduce injection volume but amplify measurement erroreach 0.01mL syringe increment represents 100mcg peptide, introducing 2040% relative error for sub-250mcg doses

Improved cardiometabolic risk factors vs placebo were observed after 24 weeks [123]

Joint Pain and Discomfort Some users report joint pain or stiffness , particularly when using higher doses

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Nephropathy is defined as elevated albuminuria, reduced eGFR (usually 25, insulin-resistant women for 26 weeks