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Therefore, apoptosis is frequently associated with the mechanisms that cause sepsis-induced cardiac depression [70,71,72]
Sze CI, Troncoso JC, Kawas C, Mouton P, Price DL, Martin LJ
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Increased AMP levels activate Adenosine Monophosphate-Activated Protein Kinase (AMPK), which contributes to lowering of glucose production by at least 2 pathways: i) increased AMPK phosphorylates CBP & CRTC2 transcription factors, which inhibits genes involved in the production of glucose (gluconeogenic genes)
However, in routine clinical practice, changes in eating experience are often reported subjectively (76), and may be difficult to distinguish from olfactory changes, xerostomia, or gastrointestinal discomfort (68, 77), thereby compromising the precision of endpoint definition
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