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Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication

CF-related diabetes (CFRD) develops in 20% to 50% of CF patients.6 The level of immunoreactive trypsinogen measured in newborns is inversely correlated with later risk of CFRD and suggests that higher degrees of EPI in infants is predictive of later CFRD.6 Schwachman-Diamond syndrome is another cause of inherited EPI, and is found to have extensive fatty replacement of acinar cells and severe reduction of fecal elastase levels.7 Additionally, Zolinger-Edison syndrome can cause EPI due to the inactivation of lipase as a result of an acidic environment within the duodenal lumen.9 Diabetes and Inflammatory Bowel Disease Insulin resistance, poor glycemic control, and long disease duration are associated with EPI in those with both type 1 and type 2 diabetes mellitus

NAC is converted to glutathione intracellularly after absorption, meaning it doesn't flood the intestinal lumen with exogenous glutathione

Who Should Approach Glutafine with Caution

The question of whether additional supplementation provides meaningful benefit on top of adequate dietary intake and normal endogenous production is exactly where the evidence gets thin

10.1016/0076-6879(95)52005-8 Biothiols Part B: Thiols in Signal Transduction and Gene Regulation 217 MeldauS.Ullman-ZeunertL.GovindG.BartramS.BaldwinI