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This led to a heavy reliance on expensive, invasive intravenous (IV) glutathione therapies for clinical treatment

Oral NAC supplementation is associated with diarrhea, indigestion, abdominal pain, vomiting, and flatulence

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Smith, C

reported an increase in the protein-bound form of glutathione in human blood after oral administration, while glutathione in the deproteinized fraction did not change [12]

doi: 10.1080/07315724.2002.10719248 256 WillersSMDevereuxGCraigLCAMcNeillGWijgaAHAbou El-MagdWet al