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An influx in calcium is reported upon activation of GLP-1R, and in combination with the activation of PKA, this results in insulin secretion [46]
The role of GLP-1R in DM is principally to regulate glycemic control by stimulating insulin secretion, inhibiting glucagon secretion, and improving insulin signaling, thereby reducing blood glucose levels
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This dynamic process is supported by clinical research
The data have shown that L-carnitine supplementation significantly scavenge free radicals and protect the cells from oxidative stress [31] by decreasing the serum MDA level and increased activity of catalase, GPX, and SOD enzymes
Moreover, it improves triglyceride clearance and the sensitivity of adipose tissue to insulin, which may prevent ectopic fat deposition [16]
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