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Shpilka, T
SUSTAIN-10 head-to-head in T2D showed GLP-3 superiority on HbA1c
Although combined therapy is still not common practice because of the relatively recent regulatory approval, these studies highlight the potential of dual GLP-1 RA + SGLT2i therapy to synergistically reduce cardiovascular disease and decelerate renal decompensation [75]
This section provides a detailed overview of the physiological mechanisms of single GLP-1 receptor agonists, GLP-1/GIP dual agonists, and GLP-1/GIP/glucagon triple agonists, with emphasis on their effects on appetite control, glycemic regulation, and energy balance
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