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Additionally, DAMPs contribute to post-injury renal tissue regeneration and scarring (97, 99, 102105)
KEAP1/NRF2 mutant cells are protected against cysteine-starvation induced ferroptosis due to elevated GCLC expression and limited glutamate accumulation, and dual targeting of cystine import and GCLC activity can overcome the resistance of NRF2 active cells to ferroptosis (Kang et al., Cell Metab 2021)
This is due to the gut-brain connection, where changes in gut bacteria can influence neurotransmitter levels, affecting mood and emotional well-being
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112,120,121,122,123 Notably, a meta-analysis (n = 399 HAPE/495 controls) confirmed the significance of the rs1799983 polymorphism in increasing HAPE risk among Asians
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