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Glucagon-like peptide 1 receptor agonists and the potential risk of pancreatic carcinoma: a pharmacovigilance study using the FDA adverse event reporting system and literature visualization analysis

Tirzepatide Research# SURPASS program (Type 2 diabetes): Five Phase 3 trials demonstrating superior HbA1c reduction compared to insulin glargine, semaglutide, and insulin degludec SURMOUNT program (Obesity): Phase 3 trials showing up to 20.9% weight loss at 72 weeks FDA approvals : Mounjaro (May 2022) for T2D

Less common risks include gallbladder disease and pancreatitis

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Gradual increases: If youre tolerating the starting dose well, we may recommend increasing to 0.25 mg twice weekly or every four days

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