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Once-monthly GLP-1 injectables are already in clinical trials, and drugs like retatrutide represent a new generation designed to last longer and work harder

Mechanistically, fibroblast therapy halts further degenerative changes in the IVD by promoting reparative fibrosis and healing

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Taken together, these findings suggest that l-carnitine is a potent drug that increases the phosphorylation of AMPK and ACC to reduce synovial inflammation in the LPS-stimulated FLS model