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This interaction promotes insulin secretion and inhibits glucagon release, contributing to reduction of glucose in blood.4 Beyond the pancreas, GLP-1 receptors are also expressed in various organs, including the brain, heart, gastrointestinal tract, lungs, liver, kidneys, adipose tissue, and skeletal muscle, contributing to its diverse physiological roles

Franco et al., 2007a

Semaglutide should be discontinued at least 2 months before planned pregnancy, whilst topiramate is now contraindicated for migraine prophylaxis in women of childbearing potential unless a Pregnancy Prevention Programme is followed with highly effective contraception

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