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The 56-week COR-I trial studied the use of Contrave in patients with a BMI of 27 or higher and found that participants taking a combination of naltrexone and bupropion lost an average of 4.8% more weight than those given a placebo
While still a subject of active research, treatments for obesity need to be conscious of the goal to maintain lean muscle mass
In the LEAD-5 trial, liraglutide (1.8 mg once daily) reduced HbA1c more than insulin glargine during the treatment period (26 weeks) [31]
STAT News cited a recently published British Medical Journal review of 37 studies, tallying an aggregate of more than 9,300 participants, in which approximately 50% of the people who started on the drugs stop taking them within one year
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