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The SELECT trial, which supports the expanded indication, enrolled patients 45 years of age and older with pre-existing cardiovascular disease and a body-mass index of 27 or greater without diabetes
Many conditions cause similar symptoms, and inappropriate supplementation may mask underlying diagnoses whilst providing no benefit
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Metabolic diseases In addition to muscle and neurodegenerative conditions, alterations in NAD + levels and mitochondrial homeostasis are also observed in aging-associated metabolic diseases, particularly those conditions impacting highly mitochondrially-active tissues such as the kidney and liver 292,293,294
Front Endocrinol (Lausanne) 14:1268619
