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doi:10.1155/2017/1617458 21

Our paradigm also did not require food deprivation: in contrast to several previous laboratory-based experiments (e.g., [51, 52]), the animals were allowed to eat in an unrestrained and practically ad libitum manner (see Methods)

Medication is billed separately in 12-week cycles

However, most experts agree that this is well below the physiological needs of most individuals

Key areas of investigation include optimal timing of initiation, identification of responsive subgroups of patients, and evaluation of synergistic effects when combining GLP-1RAs with established biologics

& Eisner, G