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Delayed gastric emptying extends the time B12 spends in the acidic stomach environment, which might initially seem beneficial
Measurements such as waist circumference or body fat percentage testing may show modest improvements
The observed threshold effect at 358.7 pg/mL (OR = 1.04 per 10 pg/mL, 95% CI: 1.001.08, P = 0.03) suggests a plateau in B12 benefit beyond this level, likely due to saturation of methionine synthase activitya mechanism consistent with non-linear enzymatic dose-response relationships, where additional B12 may not enhance methylation capacity [21]
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