A team of researchers developed a nanostructure-based GLP-1R agonist capable of crossing the BBB that significantly attenuated neuroinflammation and memory loss in an A peptide-induced mouse model of AD by inhibiting the inflammatory responses of microglia and astrocytes (Zhao et al., 2022)
Recent regulatory guidance documents, such as the 2025 Australian Therapeutic Goods Administration (TGA) guidance on the quality of listed probiotic medicines and broader discussions on LBPs from 2020, underscore the necessity for strain-level identification, validated enumeration techniques, and explicit labeling of potency and storage conditions (570, 571)
Insulin Resistance: Menopause can reduce cells' responsiveness to insulin, leading to elevated blood sugar levels and increased abdominal fat storage
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However, as prescriptions for weight-loss drugs soar, additional benefits and risks of GLP-1 drugs are emerging
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