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The tertiary structure of the enzyme is stabilized by an extensive network of salt bridges, hydrogen bonds and van der Waals interactions (Thoma et al., 2003)

Although intensive glycemic control reduces risk, it does not eliminate progression entirely

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GLP-1 agonists enhance insulin secretion and suppress glucagon release only when blood glucose levels are elevated, a glucose-dependent mechanism that substantially reduces the risk of hypoglycaemia compared to other diabetes medications such as sulphonylureas

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10.3390/nu13051602 524 ZhuR.FangY.LiH.LiuY.WeiJ.ZhangS.et al