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This approach mainly accounted for the possibility that a proportion of patients could have switched from DPP4 inhibitors to GLP1 receptor agonists during follow-up (a potential thyroid cancer risk with GLP1 receptor agonists could spill over into the group classified as receiving DPP4 inhibitors according to the intention-to-treat definition for drug use, which might lead to an underestimation of thyroid cancer risk with GLP1 receptor agonists)

Everything we know about its dosage comes from the Phase 2 trial published in the New England Journal of Medicine and the Phase 3 TRIUMPH-4 results released in late December of the previous year

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Eur J Immunol (2014) 44(2):35769