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Tirzepatide can cause acute kidney injury, particularly with severe gastrointestinal symptoms causing dehydration
This is because injections of TB4 into the hearts of mice (both injured and uninjured) basically kick-started repair processes and made the epicardium (the outermost layer of the heart) behave as it does in embryonic development
A., Chu, J., Feng, S., Guo, C., Xue, B., He, K., & Li, L
Additionally, ECs can respond to IL-1 in the bloodstream by synthesizing and releasing prostaglandin E2, which influences prostaglandin receptors on neurons and glial cells, potentially leading to CNS diseases [113]
1 and Supplementary Figs
[2] Enebo LB, et al
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