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Considerations are based on IGF-1 biology, including its influence on growth factor signaling and metabolic regulation
Bone repair protocols use 300mcg daily targeting osteoblast growth hormone receptors and MAPK signaling, while fat loss protocols use 5001,000mcg daily targeting beta-3 adrenergic receptors in adipose tissue
Plus, they carry potential risks of thyroid tumors, cancer, pancreatitis and gallbladder and kidney problems
J Steroid Biochem 33:417-421, 1989
doi: 10.1186/s12933-015-0177-4 68 ZhangYZhouHWuWShiCHuSYinTet al
The epidemiology of thyroid disease
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