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The ability to shuttle between the +1, +2, and +3 oxidation states is responsible for the versatile chemistry of vitamin B 12 , allowing it to serve as a donor of deoxyadenosyl radical (radical alkyl source) and as a methyl cation equivalent (electrophilic alkyl source)

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CTCs show significantly increased tumorigenicity and metastatic potential in a novel orthotopic syngeneic model of metastatic cancer [52]

Unlike with many of the other vitamins, B12 is not synthesized by the body