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For example, in the STEP 1 trial , patients taking semaglutide lost an average of 14.9% of their body weight over 68 weeks , compared with just 2.4% in the placebo group (NEJM study)
The liver was quickly removed and weighed
This chronic lipid burden impairs mitochondrial function and elevates reactive oxygen species (ROS) levels, 11 causing oxidative stress and hepatocellular injury
Ensure that any compounded GLP-1s (like semaglutide or tirzepatide) you use are sourced exclusively from state-licensed 503A compounding pharmacies or FDA-registered 503B outsourcing facilities
Patients usually do not need to use a disinfectant on the skin, but if they do, they should allow it to dry completely before injecting
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