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Summary: GLP-1 medications do not lose their pharmacological effectiveness over time, but weight loss typically plateaus after 612 months due to metabolic adaptation and reduced energy requirements
however, both were significantly better than insulin glargine
Unlike older secretagogues, ipamorelin is highly selective it stimulates GH release without significantly affecting cortisol, prolactin, or appetite
And finally, in patients with diabetes secondary to chronic pancreatitis, a similar incretin deficiency develops early in the development of diabetes, and reduced effects of the incretin hormones are also similar to those observed in the classical obese type 2 diabetic patients (311)
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