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Long-Term Weight Management After Medication Weight loss medications are powerful tools, but they work best when combined with sustainable lifestyle changes

With metformin or a sulfonylurea plus an SGLT2 inhibitor

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For patients experiencing significant side effects despite these measures, alternative medications within the same class or different therapeutic approaches may be considered after shared decision-making with their healthcare provider

That shortage exemption started closing in late 2024

But the physiological effects on gastric emptying, insulin sensitivity, and fat oxidation persist