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Tiba AT et al
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A study of orforglipron (LY3502970) in adult participants with obesity or overweight with weight-related comorbidities (ATTAIN-1)
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In either case, this leads to amplification of pro-survival (Akt) and proliferation (MAPK) signals ultimately generating an enhanced anabolic response in osteogenic cells
High-density lipoprotein cholesterol (HDL-C) changes are variable and generally minimal, with some studies showing slight increases and others showing no significant change
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