A recent study demonstrated that GLP-1 enhances preingestive satiety through hypothalamic circuits in both mice and humans, with GLP-1R-expressing neurons in the dorsomedial hypothalamus (DMH) emerging as key candidates for encoding this satiety signal [24]
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They bypass the blood-brain barrier
Tirzepatide does not directly trigger lipolysis in the same way as peptides designed to target fat metabolism
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