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It is estimated that approximately 936 million adults worldwide suffer from moderate-to-severe OSAS, the vast majority of whom remain undiagnosed (3)

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therefore, new research on the potential of GST-P1 usage as a screening test in patients within the grey-area of PSA values could bring valuable new information for the development of novel methods of identifying patients with PC

While a substitution with the polar serine at position 13 retained wild-type dehydratase activity, presumably due to the alcohols ability to assume cysteines function in stabilizing deprotonated GS , the only other Pt GSTF8 variants to keep analbeit reducedflavan-3,3,4-triol ( 4 ) dehydration activity contained a glycine, alanine or asparagine mutation (Fig