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Most side effects resolve on their own after reaching a stable maintenance dose

However, tirzepatide also activates the glucose-dependent insulinotropic polypeptide (GIP) receptor , resulting in potentially enhanced weight loss and better glycemic control

The surface expression level of GLP-1R in HEK-Blue GLP-1 cells is consistent with physiological GLP-1R density reported in the literature

However, discontinuing semaglutide may lead to weight regain, emphasizing the importance of adopting lifestyle changes for lasting weight control

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Nausea was common