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An observational cohort study published in July 2024 sought to answer this question

Patients whose HbA1c was lower than their pre-GLP-1 level at three months most often had improvement at twelve months as well (55%)

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A year later the FDA convened its Bone, Reproductive and Urologic Drugs Advisory Committee to settle, in the abstract, the question that had killed the application

Approximately 50% of patients regain significant weight after discontinuing tirzepatide, particularly within the first 12 months post-stop