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GH secretagogues stimulate fat oxidation and may enhance energy expenditure during calorie restriction or fasting. Heffernan et al., Frontiers in Endocrinology 4

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Patients with significant visceral fat burden see the clearest benefit from tesamorelin

This single reaction sits at the intersection of two critical metabolic axes: The folate cycle axis: 5-MTHF is the methyl donor that MTR uses to regenerate methionine from homocysteine, simultaneously regenerating tetrahydrofolate (THF) that feeds back into one-carbon metabolism for nucleotide synthesis (thymidylate and purine biosynthesis)

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DAO also modulates type II alveolar epithelial cell senescence via the p53/p21 pathway