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The appetite suppression makes hitting protein targets difficult, requiring deliberate meal planning
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Its mechanism targets cellular energy production, and morning dosing allows the peptide to act during the bodys peak metabolic period
Individuals must not extrapolate figures from other peptides and treat them as applicable to retatrutide
Understanding these differences helps set appropriate expectations
In the landmark STEP 1 trial, published in the New England Journal of Medicine in 2021, patients taking semaglutide 2.4 mg (Wegovy) lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group
