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Finally, long-standing diabetes patients require an exogenous insulin injection to sustain high-insulin concentration, which is the so-called exogenous hyperinsulinemia. Moreover, a unique portal structure enables insulin secreted from the pancreatic islet to perfuse the exocrine pancreas first, significantly increasing the regional insulin concentration in PDA tissue

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Specifically, we investigated the potential mediating roles of T2D and obesity in this relationship

doi: 10.1210/jc.2003-030835 37 KapodistriaKTsilibaryEPKotsopoulouEMoustardasPKitsiouP

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