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Joint Pain and Function Research in rats indicates that injections of AOD9604 directly into arthritic joints can work in synergy with existing therapies to improve pain, reduce disability, and improve quality of life

However, its important to note that the duration of benefits can be influenced by several factors, as discussed in the previous section

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This is thought to have several effects: It may help muscles absorb glucose without needing insulin, build more mitochondria, burn fat, and reduce inflammation

So, while the debate between localized and systemic application will likely continue, the most consistent and logically sound approach for targeted ankle research points toward a localized, subcutaneous injection near the site of injury

The experimental murine models appeared to have exhibited improved fitness, better renal functioning, and increased fur density