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SGLT2-i reduces both systolic blood pressure (SBP) and diastolic blood pressure (DBP) across multiple trials and meta-analyses with reductions up to 8.6/4.3 mmHg, depending on the agent, dose and population studied

This is the pathway most researchers already know from compounds such as Semaglutide

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In the gut specifically, KPV is absorbed through a dedicated intestinal transporter (PepT1), allowing it to calm inflammation directly inside epithelial cells