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For oral administration in mice, NR and NMN are first metabolized by the liver or GI tract into NAM, which can then be taken up by other tissues

Therefore, if GLP-1 RA treatment specifically increases the risk of pancreatitis in this vulnerable population, such an effect would likely remain undetected in randomized trials

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Zhou Y-X, Zhang H, Peng C (2014) Puerarin: a review of pharmacological effects

The key preclinical data urgently needed before clinical trials can commence include: (i) efficacy and immune-profiling data derived strictly from clinically relevant orthotopic and spontaneous pulmonary metastasis models, rather than simple ectopic subcutaneous models

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