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not predominantly hepatic CYP-dependent Key adverse effect to watch / transient hypertension (systolic rise of 6 mmHg on average in trials) Nausea incidence / 40% in clinical trials, may worsen with hepatic congestion FDA approval year / 2019 for hypoactive sexual desire disorder in premenopausal women How Bremelanotide Works: Melanocortin Receptor Activation Bremelanotide is a synthetic cyclic heptapeptide that activates melanocortin-4 receptors (MC4R) in the central nervous system

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